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The target itself was validated by a 2014 Nature study showing NNMT knockdown in mouse fat and liver protected against diet-induced obesity by augmenting cellular energy expenditure (Kraus 2014, PMID 24717514) [2]

Thats a real metabolic benefit, but a different category of outcome than prescription GLP-1 therapy

But meat isnt the only problem

Cycling Protocols Standard cycling involves 4-8 weeks of daily use followed by an equal off period before resuming if needed